CHARACTERIZATION OF HEMATOPOIESIS IN SICKLE CELL DISEASE BY PROSPECTIVE ISOLATION OF STEM AND PROGENITOR CELLS

Characterization of Hematopoiesis in Sickle Cell Disease by Prospective Isolation of Stem and Progenitor Cells

The consequences of sickle cell disease (SCD) include ongoing hematopoietic stress, hemolysis, vascular damage, and effect of chronic therapies, such as blood transfusions and hydroxyurea, on hematopoietic stem and progenitor cell (HSPC) have been poorly characterized.We have quantified the frequencies of nine HSPC populations by flow cytometry in

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Climate Litigation & Climate Justice

Human rights arguments have been successful before several domestic courts across Europe in imposing more ambitious action in cutting greenhouse gas emissions upon governments.Yet, the integration of climate justice concerns in those judicial decisions have been insufficiently studied.This paper seeks to contribute to such endeavor by analyzing the

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Prenatal exposure to dietary fat induces changes in the transcriptional factors, TEF and YAP, which may stimulate differentiation of peptide neurons in rat hypothalamus.

Gestational exposure to a high-fat diet (HFD) stimulates the differentiation of orexigenic peptide-expressing neurons in the hypothalamus of offspring.To examine possible mechanisms that mediate this phenomenon, this study investigated the transcriptional factor, transcription enhancer factor-1 (TEF), and co-activator, Yes-associated protein (YAP),

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